PROW: CD88

PROW and IWHLDA present the GUIDE on:
CD88
Author: Teizo Fujita
Reviewer: Francois Boulay
Link to additional info in FORUM [GUIDE BAR]

ALTERNATE NAMES FOR CD88

C5a receptor
C5aR

MAJOR LINKS FOR CD88

NCBI LocusLink Record: 728
Mendelian Inheritance in Man (OMIM): 113995
SwissProt annotated protein record: P21730

FUNCTION BIOCHEMICAL ACTIVITY OF CD88

The C5a-occupied receptor stimulates the GTPase activity of Gi2**

CELLULAR FUNCTION OF CD88

C5a-mediated inflammation
Activation of granulocytes

DISEASE RELEVANCE OF CD88 AND FUNCTION OF CD88 IN INTACT ANIMAL

CD88 appears necessary to protect mice against Pseudomonas aeruginosa**

STRUCTURE MOLECULAR FAMILY FOR CD88

Families in which CD88 is a member
- CD88-->G-protein coupled receptors

MOLECULAR STRUCTURE OF CD88

350 amino acids with a calculated mass of 39 320
Seven hydrophobic membrane-spanning regions
G-protein-coupled receptor

MOLECULAR MASS OF CD88

CELL TYPE	MW UNREDUCED	MW REDUCED	Comment
Neutrophil	43 kDa
Monocytes	43 kDa

POST-TRANSCRIPTIONAL MODIFICATION OF CD88 - No information

POST-TRANSLATIONAL MODIFICATION OF CD88

Glycosylated
CD88 is phosphorylated in response to C5a or after stimulation of cells with phorbol esters**

MOLECULAR INTERACTIONS PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD88 - No information

SUBSTRATES FOR CD88 - No information

ENZYMES WHICH MODIFY CD88 - No information

LIGANDS FOR CD88 AND MOLECULES ASSOCIATED WITH CD88

MOLECULE	COMMENT
C5a/C5a(desArg)
Anaphylatoxin

EXPRESSION MAIN CELLULAR EXPRESSION OF CD88 Link to additional info in FORUM

Granulocytes
Monocytes
Dendritic cells**
Hepatoma-derived cell line HepG2**
Astrocytes**
Microglia**

AUTHOR'S ADDITIONAL INSIGHTS ON CD88 - No information

REAGENTS CD88-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
4C8
MC512

SELECTION OF OTHER CD88-SPECIFIC REFERENCE MAB - No information

SELECTED REFERENCES ON CD88

REVIEWS

1. Gerard C,Gerard NP C5A anaphylatoxin and its seven transmembrane-segment receptor. Annu Rev Immunol 1994 12:775 PubMed

2. Oppermann. 1995. Leukocyte Typing V. 953-954

PRIMARY CITATIONS

3. Boulay F,Mery L,Tardif M,Brouchon L,Vignais P Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells. Biochemistry 1991 30:2993 PubMed

4. Gerard NP,Gerard C The chemotactic receptor for human C5a anaphylatoxin. Nature 1991 349:614 PubMed

5. Hopken UE,Lu B,Gerard NP,Gerard C The C5a chemoattractant receptor mediates mucosal defence to infection. Nature 1996 383:86 ** PubMed

6. Watanabe H,Kuraya M,Kasukawa R,Yanagisawa H,Yanagisawa M,Fujita T Analysis of C5a receptor by monoclonal antibody. J Immunol Methods 1995 185:19 PubMed

7. Ye RD,Boulay F Structure and function of leukocyte chemoattractant receptors. Adv Pharmacol 1997 39:221 PubMed

WWW RESOURCES

* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99 mpr@mail.nih.gov