• B7
• BB1

MAJOR LINKS FOR CD80  

• NCBI LocusLink Record: 941
• Mendelian Inheritance in Man (OMIM): 112203
• SwissProt annotated protein record: P33681

CELLULAR FUNCTION OF CD80  

• Co-regulator of T cell activation with CD86

DISEASE RELEVANCE OF CD80 AND FUNCTION OF CD80 IN INTACT ANIMAL  

• Involved in the alloactivation of T cells
• Critical role of CD80 in autoimmune, humoral, and transplant responses, etc**

• Families in which CD80 is a member
  • CD80-->immunoglobulin supergene family

MOLECULAR STRUCTURE OF CD80  

• The extracellular region contains one V-type Ig domain and one C-type Ig domain, both highly glycosylated
• Transmembrane domain
• Relatively short intracellular tail (16-31 amino acids depending on species and splice variant)*

MOLECULAR MASS OF CD80  

POST-TRANSCRIPTIONAL MODIFICATION OF CD80  

• There is alternative splicing of two cytoplasmic exons**

POST-TRANSLATIONAL MODIFICATION OF CD80  

• Eight N-linked glycosylation sites

SUBSTRATES FOR CD80   - No information

ENZYMES WHICH MODIFY CD80   - No information

LIGANDS FOR CD80 AND MOLECULES ASSOCIATED WITH CD80  

• Activated B cells
• Activated T cells**
• Macrophages**

SELECTION OF OTHER CD80-SPECIFIC REFERENCE MAB  

REVIEWS

PRIMARY CITATIONS

1. Engel, P., Wagner, N. and Tedder, T.F. In Leucocyte Typing V ed. Schlossman et al p 682-684 (1996)

2. Freedman AS,Freeman G,Horowitz JC,Daley J,Nadler LM B7, a B-cell-restricted antigen that identifies preactivated B cells. J Immunol 1987 139:3260 PubMed

3. Freeman GJ,Disteche CM,Gribben JG,Adler DA,Freedman AS,Dougery J,Nadler LM The gene for B7, a costimulatory signal for T-cell activation, maps to chromosomal region 3q13.3-3q21. Blood 1992 79:489 PubMed

4. Freeman GJ,Freedman AS,Segil JM,Lee G,Whitman JF,Nadler LM B7, a new member of the Ig superfamily with unique expression on activated and neoplastic B cells. J Immunol 1989 143:2714 PubMed

5. Freeman GJ,Gray GS,Gimmi CD,Lombard DB,Zhou LJ,White M,Fingeroth JD,Gribben JG,Nadler LM Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7. J Exp Med 1991 174:625 PubMed

6. Linsley PS,Bradshaw J,Greene J,Peach R,Bennett KL,Mittler RS Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement. Immunity 1996 4:535 PubMed

7. Linsley PS,Brady W,Urnes M,Grosmaire LS,Damle NK,Ledbetter JA CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med 1991 174:561 PubMed

8. Linsley PS,Clark EA,Ledbetter JA T-cell antigen CD28 mediates adhesion with B cells by interacting with activation antigen B7/BB-1. Proc Natl Acad Sci U S A 1990 87:5031 PubMed

9. Yokochi T,Holly RD,Clark EA B lymphoblast antigen (BB-1) expressed on Epstein-Barr virus-activated B cell blasts, B lymphoblastoid cell lines, and Burkitt's lymphomas. J Immunol 1982 128:823 PubMed

WWW RESOURCES

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov