• E-selectin
• ELAM-1
• LECAM-2

MAJOR LINKS FOR CD62E  

• NCBI LocusLink Record: 6401
• Mendelian Inheritance in Man (OMIM): 131210
• SwissProt annotated protein record: P16581

CELLULAR FUNCTION OF CD62E  

• CD62E mediates leukocyte rolling on activated endothelium at inflammatory sites
• CD62E may also support tumor cell adhesion during hematogenous metastasis, and play a role in angiogenesis**

DISEASE RELEVANCE OF CD62E AND FUNCTION OF CD62E IN INTACT ANIMAL  

• Function-blocking antibodies have been reported to decrease leukocyte-mediated damage in a rodent model of lung inflammation**
• In CD62E KO mice, there are no significant changes in the recruitment of leukocytes in certain models of inflammation. However, abnormalities are observed in CD62E KO mice when the function of CD62P is also blocked, and double KO mice (CD62E + CD62P) show diminished resistance to opportunistic infections**
• Similarly, patients with LADII syndrome, who lack the sialyl Lewis x component of the selectin counter-receptors, suffer recurrent pyogenic infections**

• Families in which CD62E is a member
  • CD62E-->selectin-->c-type lectin

MOLECULAR STRUCTURE OF CD62E  

• 589 amino acids (extracellular region: 535 aa, transmembrane region: 22 aa, intracellular region: 32 aa)
• One C-type lectin domain (N-terminus)*
• One EGF-like domain*
• Six SCR domains are present in the extracellular region

MOLECULAR MASS OF CD62E  

POST-TRANSCRIPTIONAL MODIFICATION OF CD62E   - Unknown

POST-TRANSLATIONAL MODIFICATION OF CD62E  

• Eleven possible N-linked glycosylation sites are present in the extracellular region*

SUBSTRATES FOR CD62E   - Unknown

ENZYMES WHICH MODIFY CD62E   - Unknown

LIGANDS FOR CD62E AND MOLECULES ASSOCIATED WITH CD62E  

• CD62E is expressed on acutely activated endothelium
• CD62E is also expressed on endothelium in chronic inflammatory lesions of the skin and synovium*
• In addition, non-inflammatory expression of CD62E has been observed in endothelium in skin, placenta and bone marrow**

SELECTION OF OTHER CD62E-SPECIFIC REFERENCE MAB  

REVIEWS

PRIMARY CITATIONS

1. Berg EL,Yoshino T,Rott LS,Robinson MK,Warnock RA,Kishimoto TK,Picker LJ,Butcher EC The cutaneous lymphocyte antigen is a skin lymphocyte homing receptor for the vascular lectin endothelial cell-leukocyte adhesion molecule 1. J Exp Med 1991 174:1461 PubMed

2. Bevilacqua MP,Pober JS,Mendrick DL,Cotran RS,Gimbrone MA Jr Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci U S A 1987 84:9238 ** PubMed

3. Bevilacqua MP,Stengelin S,Gimbrone MA Jr,Seed B Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science 1989 243:1160 PubMed

4. Carlos T,Kovach N,Schwartz B,Rosa M,Newman B,Wayner E,Benjamin C,Osborn L,Lobb R,Harlan J Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1. Blood 1991 77:2266 PubMed

5. Cotran RS,Gimbrone MA Jr,Bevilacqua MP,Mendrick DL,Pober JS Induction and detection of a human endothelial activation antigen in vivo. J Exp Med 1986 164:661 PubMed

6. Groves RW,Allen MH,Barker JN,Haskard DO,MacDonald DM Endothelial leucocyte adhesion molecule-1 (ELAM-1) expression in cutaneous inflammation. Br J Dermatol 1991 124:117 PubMed

7. Koch AE,Burrows JC,Haines GK,Carlos TM,Harlan JM,Leibovich SJ Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues. Lab Invest 1991 64:313 PubMed

8. Koch AE,Halloran MM,Haskell CJ,Shah MR,Polverini PJ Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature 1995 376:517 PubMed

9. Lawrence MB,Springer TA Neutrophils roll on E-selectin. J Immunol 1993 151:6338 PubMed

10. Pober JS,Bevilacqua MP,Mendrick DL,Lapierre LA,Fiers W,Gimbrone MA Jr Two distinct monokines, interleukin 1 and tumor necrosis factor, each independently induce biosynthesis and transient expression of the same antigen on the surface of cultured human vascular endothelial cells. J Immunol 1986 136:1680 PubMed

11. Walz G,Aruffo A,Kolanus W,Bevilacqua M,Seed B Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells. Science 1990 250:1132 PubMed

WWW RESOURCES

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov