• From: David Parker     Date: 07/31/97
  Subject: Murine knockouts show CD21 function on B cells

  The murine knockouts show an important function of CD21 on B cells in both T cell-dependent and type 2 T-cell independent responses.

  Ahearn JM, Fischer MB, Croix D, Goerg S, Ma M, Xia J, Zhou X, Howard RG, Rothstein TL and Carroll MC. Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen. Immunity 1996 4:251 PubMed

  Croix DA, Ahearn JM, Rosengard AM, Han S, Kelsoe G, Ma M and Carroll MC. Antibody response to a T-dependent antigen requires B cell expression of complement receptors. J Exp Med 1996 183:1857 PubMed
  
  

Modified 10/14/99   mpr@mail.nih.gov