• AlphaX integrin chain
• Axb2
• CR4
• leukocyte surface antigen p150,95

MAJOR LINKS FOR CD11c  

• NCBI LocusLink Record: 3687
• Mendelian Inheritance in Man (OMIM): 151510
• SwissProt annotated protein record: P20702

CELLULAR FUNCTION OF CD11c  

• Similar functions to CD11b/CD18 with which it cooperates
• Major CD11/CD18 receptor on tissue macrophages

DISEASE RELEVANCE OF CD11c AND FUNCTION OF CD11c IN INTACT ANIMAL  

• Absent in Leukocyte Adhesion Deficiency (LAD-1) patients

• Families in which CD11c is a member
  • CD11c-->integrin alpha chains-->integrin assemblies

MOLECULAR STRUCTURE OF CD11c  

• Type 1 transmembrane protein; 1144 amino acids
• 1081aa extracellular
• 26aa transmembrane
• 29aa cytoplasmic
• The I domain for CD11c has not yet been crystallized and expressed in isolated form but has been described to have ligand binding activity.
• The seven repeating integrin domains (I-VII) have been modeled to resemble a beta-propeller fold (Springer, 1997)

MOLECULAR MASS OF CD11c  

POST-TRANSCRIPTIONAL MODIFICATION OF CD11c   - No information

POST-TRANSLATIONAL MODIFICATION OF CD11c  

• 10 potential N-glycosylation sites

SUBSTRATES FOR CD11c   - No information

ENZYMES WHICH MODIFY CD11c   - No information

LIGANDS FOR CD11c AND MOLECULES ASSOCIATED WITH CD11c  

• CD11c/CD18 binds similar ligands as CD11b/CD18 although not as well characterized

• Monocytes (high)
• Macrophages (high)
• NK cells (high)
• Granulocytes (moderate)
• Subset of T cells (least)
• Subset of B cells (least)

• CD11c/CD18 mediates leukocyte spreading onto protein-coated surfaces, a function suggestive of a role in cell survival, as has been already proposed for CD11b (Coxon A et al 1996)**

SELECTION OF OTHER CD11c-SPECIFIC REFERENCE MAB  

REVIEWS

1. Corbi, A.L. In 'Leukocyte Integrins: structure, expression and function'.Springer (Heidelberg, Germany)/R.G. Landes (Gergetown, Texas) Ed, 1996 **

2. Petty HR,Todd RF 3d Integrins as promiscuous signal transduction devices. Immunol Today 1996 17:209 PubMed

3. Springer TA Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 1994 76:301 PubMed

4. Stewart M,Thiel M,Hogg N Leukocyte integrins. Curr Opin Cell Biol 1995 7:690 PubMed

PRIMARY CITATIONS

5. Corbi AL,Miller LJ,O'Connor K,Larson RS,Springer TA cDNA cloning and complete primary structure of the alpha subunit of a leukocyte adhesion glycoprotein, p150,95. EMBO J 1987 6:4023 PubMed

6. Coxon A,Rieu P,Barkalow FJ,Askari S,Sharpe AH,von Andrian UH,Arnaout MA,Mayadas TN A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 1996 5:653 ** PubMed

7. Lopez-Rodriguez C,Chen HM,Tenen DG,Corbi AL Identification of Sp1-binding sites in the CD11c (p150,95 alpha) and CD11a (LFA-1 alpha) integrin subunit promoters and their involvement in the tissue-specific expression of CD11c. Eur J Immunol 1995 25:3496 PubMed

8. Lopez-Rodriguez C,Kluin-Nelemans HC,Corbi AL AP-1 regulates the basal and developmentally induced transcription of the CD11c leukocyte integrin gene. J Immunol 1996 156:3780 PubMed

9. Noti JD,Reinemann BC,Petrus MN Sp1 binds two sites in the CD11c promoter in vivo specifically in myeloid cells and cooperates with AP1 to activate transcription. Mol Cell Biol 1996 16:2940 PubMed

10. Sanchez-Madrid F,Nagy JA,Robbins E,Simon P,Springer TA A human leukocyte differentiation antigen family with distinct alpha- subunits and a common beta-subunit: the lymphocyte function-associated antigen (LFA-1), the C3bi complement receptor (OKM1/Mac-1), and the p150,95 molecule. J Exp Med 1983 158:1785 PubMed

11. Springer TA Folding of the N-terminal, ligand-binding region of integrin alpha- subunits into a beta-propeller domain. Proc Natl Acad Sci U S A 1997 94:65 PubMed

WWW RESOURCES

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99   mpr@mail.nih.gov