PROW: CD37

PROW and IWHLDA present the GUIDE on:
CD37
Author: Gerhard Moldenhauer
Reviewer: Vaclav Horejsi
[GUIDE BAR]

ALTERNATE NAMES FOR CD37

gp52-40

MAJOR LINKS FOR CD37

NCBI LocusLink Record: 951
Mendelian Inheritance in Man (OMIM): 151523
SwissProt annotated protein record: P11049

FUNCTION BIOCHEMICAL ACTIVITY OF CD37 - No information

CELLULAR FUNCTION OF CD37

Involved in signal transduction

DISEASE RELEVANCE OF CD37 AND FUNCTION OF CD37 IN INTACT ANIMAL

Stable marker for malignancies derived from mature B cells, like B-CLL, HCL, and all types of B-NHL

STRUCTURE MOLECULAR FAMILY FOR CD37

Families in which CD37 is a member
- CD37-->TM4SF

MOLECULAR STRUCTURE OF CD37

Polypeptide of 281 AA bearing 3 potential N-glycosylation sites (Classon et al. 1990)

MOLECULAR MASS OF CD37

CELL TYPE	MW UNREDUCED	MW REDUCED	Comment
Lymphoblastoid B cell line	40-52 kDa	40-52 kDa

POST-TRANSCRIPTIONAL MODIFICATION OF CD37 - No information

POST-TRANSLATIONAL MODIFICATION OF CD37

Heavily N-glycosylated, protein core 26 kDa; generally two N-glycosylation sites are used, but sometimes a third site is occupied (Schwartz-Albiez
et al. 1988)

MOLECULAR INTERACTIONS PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD37 - No information

SUBSTRATES FOR CD37 - No information

ENZYMES WHICH MODIFY CD37 - No information

LIGANDS FOR CD37 AND MOLECULES ASSOCIATED WITH CD37

MOLECULE	COMMENT
CD53	See Note 1
CD81	See Note 1
CD82	See Note 1
MHC class II	See Note 1

Note 1: Formation of large complexes at the surface of B cells composed of CD37, CD53, CD81 and CD82 together with MHC class II molecules (Angelisova et al. 1994)

EXPRESSION MAIN CELLULAR EXPRESSION OF CD37

Strongly expressed on normal and neoplastic mature sIg+ B cells
At low levels also present on resting and activated T cells, neutrophils, granulocytes, and monocytes

AUTHOR'S ADDITIONAL INSIGHTS ON CD37

Gene mapped to region p13-q13.4 on chromosome 19 (Virtaneva et al. 1993)

REAGENTS CD37-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP - No information

SELECTION OF OTHER CD37-SPECIFIC REFERENCE MAB

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
HD28	(Schwartz-Albiez et al. 1988)
G28-1	(Ledbetter et al., 1987)
MB-1	(Link et al. 1986)
M-B371	(P Rieber, Dresden, Germany)
IPO-24	(Sidorenko et al. 1992)

SELECTED REFERENCES ON CD37

REVIEWS

1. Wright MD,Tomlinson MG The ins and outs of the transmembrane 4 superfamily. Immunol Today 1994 15:588 PubMed

PRIMARY CITATIONS

2. Angelisova P,Hilgert I,Horejsi V Association of four antigens of the tetraspans family (CD37, CD53, TAPA- 1, and R2/C33) with MHC class II glycoproteins. Immunogenetics 1994 39:249 PubMed

3. Classon BJ,Williams AF,Willis AC,Seed B,Stamenkovic I The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. J Exp Med 1990 172:1007 PubMed

4. Ledbetter, J.A., Shu, G., and Clark, E.A. 1987. Leucocyte Typing III, pp. 339-340.

5. Link MP,Bindl J,Meeker TC,Carswell C,Doss CA,Warnke RA,Levy R A unique antigen on mature B cells defined by a monoclonal antibody. J Immunol 1986 137:3013 PubMed

6. Schwartz-Albiez R,Dorken B,Hofmann W,Moldenhauer G The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein. J Immunol 1988 140:905 PubMed

7. Sidorenko SP,Vetrova EP,Yurchenko OV,Berdova AG,Shlapatskaya LN,Gluzman DF Monoclonal antibodies of IPO series against B cell differentiation antigens in leukemia and lymphoma immunophenotyping. Neoplasma 1992 39:3 PubMed

8. Virtaneva KI,Angelisova P,Baumruker T,Horejsi V,Nevanlinna H,Schroder J The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes. Immunogenetics 1993 37:461 PubMed

WWW RESOURCES

* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99 mpr@mail.nih.gov