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CELLULAR FUNCTION OF CD25 - IL-2 receptor
DISEASE RELEVANCE OF CD25 AND FUNCTION OF CD25 IN INTACT ANIMAL
MOLECULAR STRUCTURE OF CD25 - Type I transmembrane molecule
| CELL TYPE | MW UNREDUCED | MW REDUCED | Comment |
|---|---|---|---|
| Lymphocytes | 55kDa | 55kDa* |
POST-TRANSCRIPTIONAL MODIFICATION OF CD25 - No information
POST-TRANSLATIONAL MODIFICATION OF CD25
| MOLECULE | COMMENT |
|---|---|
| Stat5 | Transcription factor binds an IL-2 responsive element in CD25 promoter |
| Elf-1 | Transcription factor binds an IL-2 responsive element in CD25 promoter |
| HGG-I(Y) | Transcription factor binds an IL-2 responsive element in CD25 promoter |
| GATA | Transcription factor binds an IL-2 responsive element in CD25 promoter |
| Tax from HTLV-1 |
SUBSTRATES FOR CD25 - No information
ENZYMES WHICH MODIFY CD25 - No information
LIGANDS FOR CD25 AND MOLECULES ASSOCIATED WITH CD25
| MOLECULE | COMMENT |
|---|---|
| IL-2 (interleukin-2) | |
| CD122 (IL-2R beta) | High-affinity IL-2 receptor consists of CD25, CD122 and CD132 |
| CD132 (IL-2R gamma) | High-affinity IL-2 receptor consists of CD25, CD122 and CD132 |
| NAME(Workshop IDs) | SOURCE or REFERENCE | COMMENT |
|---|---|---|
| 7G7B6 (C-25) | David L Nelson, Bethesda | |
| MEM-145 (C-53) | Vaclav Horejsi, Praha | |
| Wu949 (C-55) | Zhiyou Wang, Wuhan | |
| MEM-181 (N-L024) | Vaclav Horejsi, Praha |
SELECTION OF OTHER CD25-SPECIFIC REFERENCE MAB
| NAME(Workshop IDs) | SOURCE or REFERENCE | COMMENT |
|---|---|---|
| anti-Tac | Takashi Uchiyama, T et al. 1981 | |
| 2A3 | DL Urdal, DL et al. 1984 | |
| H-31 | Y Tanaka, et al. 1985 |
REVIEWS
1. Sugamura K,Asao H,Kondo M,Tanaka N,Ishii N,Nakamura M,Takeshita T The common gamma-chain for multiple cytokine receptors. Adv Immunol 1995 59:225 PubMed
2. Tanaka Y,Tozawa H,Hayami M,Sugamura K,Hinuma Y Distinct reactivities of four monoclonal antibodies with human interleukin 2 receptor. Microbiol Immunol 1985 29:959 PubMed
3. Taniguchi T,Minami Y The IL-2/IL-2 receptor system: a current overview. Cell 1993 73:5 ** PubMed
4. Uchiyama T,Broder S,Waldmann TA A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J Immunol 1981 126:1393 PubMed
5. Uchiyama T,Nelson DL,Fleisher TA,Waldmann TA A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells. J Immunol 1981 126:1398 PubMed
6. Urdal DL,March CJ,Gillis S,Larsen A,Dower SK Purification and chemical characterization of the receptor for interleukin 2 from activated human T lymphocytes and from a human T- cell lymphoma cell line. Proc Natl Acad Sci U S A 1984 81:6481 PubMed
7. Waldmann TA The interleukin-2 receptor. J Biol Chem 1991 266:2681 ** PubMed
PRIMARY CITATIONS
8. Cosman D,Cerretti DP,Larsen A,Park L,March C,Dower S,Gillis S,Urdal D Cloning, sequence and expression of human interleukin-2 receptor. Nature 1984 312:768 PubMed
9. Leonard WJ,Depper JM,Crabtree GR,Rudikoff S,Pumphrey J,Robb RJ,Kronke M,Svetlik PB,Peffer NJ,Waldmann TA,et al Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 1984 311:626 PubMed
10. Nikaido T,Shimizu A,Ishida N,Sabe H,Teshigawara K,Maeda M,Uchiyama T,Yodoi J,Honjo T Molecular cloning of cDNA encoding human interleukin-2 receptor. Nature 1984 311:631 PubMed
11. Uchiyama T,Broder S,Waldmann TA A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. I. Production of anti-Tac monoclonal antibody and distribution of Tac (+) cells. J Immunol 1981 126:1393 ** PubMed
Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission
Modified 10/14/99 mpr@mail.nih.gov