• From: Richard Lake     Date: 01/18/98
  Subject: CD2 transcriptional enhancer

  At least six proteins bind to the CD2 enhancer which is located 3' to the gene. These include elf1, a member of the ets family and sox4, a member of the HMG family of transcription factors.

  Lake RA, Wotton D and Owen MJ. A 3' transcriptional enhancer regulates tissue-specific expression of the human CD2 gene. EMBO J. 1990 9:3129 PubMed

  Wotton D, Lake RA, Farr CJ and Owen MJ. The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer. J. Biol. Chem. 1995 270:7515 PubMed
  
  

Modified 10/14/99   mpr@mail.nih.gov