PROW: CDw17

PROW and IWHLDA present the GUIDE on:
CDw17
Author: Sanna M. Goyert
Reviewer: John S. Thompson
[GUIDE BAR]

ALTERNATE NAMES FOR CDw17

lactosylceramide, LacCer

MAJOR LINKS FOR CDw17

No information

FUNCTION BIOCHEMICAL ACTIVITY OF CDw17 - No information

CELLULAR FUNCTION OF CDw17

Function is unknown
LacCer binds to bacteria and may function in phagocytosis

DISEASE RELEVANCE OF CDw17 AND FUNCTION OF CDw17 IN INTACT ANIMAL - No information

STRUCTURE MOLECULAR FAMILY FOR CDw17

Families in which CDw17 is a member
- CDw17-->LacCer
- CDw17-->carbohydrates with CD designation

MOLECULAR STRUCTURE OF CDw17

The lactosyl disaccharide group of the glycosphingolipid lactosyl ceramide (LaCer): Galbl -> 4Glcb1 -> 1Cer

MOLECULAR MASS OF CDw17

CELL TYPE	MW UNREDUCED	MW REDUCED	Comment
Diverse	150-160 kDa	120 kDa

POST-TRANSCRIPTIONAL MODIFICATION OF CDw17 - No information

POST-TRANSLATIONAL MODIFICATION OF CDw17 - No information

MOLECULAR INTERACTIONS PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CDw17 - No information

SUBSTRATES FOR CDw17 - No information

ENZYMES WHICH MODIFY CDw17 - No information

LIGANDS FOR CDw17 AND MOLECULES ASSOCIATED WITH CDw17 - No information

EXPRESSION MAIN CELLULAR EXPRESSION OF CDw17

Monocytes
Granulocytes
Basophils
Platelets
A subset of peripheral B cells (CD19+)
Tonsillar dendritic cells
It is rapidly and extensively down-modulated on activated granulocytes but is up-modulated on IL-2 activated T lymphocytes (Gyimesi et al. 1995)**

AUTHOR'S ADDITIONAL INSIGHTS ON CDw17 - No information

REAGENTS CDw17-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP - No information

SELECTION OF OTHER CDw17-SPECIFIC REFERENCE MAB

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
GO35 (MR19)	Thompson JS et al. 1987

SELECTED REFERENCES ON CDw17

REVIEWS

PRIMARY CITATIONS

1. Fureder W,Agis H,Sperr WR,Lechner K,Valent P The surface membrane antigen phenotype of human blood basophils. Allergy 1994 49:861 PubMed

2. Gyimesi, E., Kiss, E., Suranyi, P. and Szegedi, G. Leukocyte Typing V (ed.Schlossman et al.) pp. 1067-1068. Oxford University Press, Oxford (1995)

3. Karlsson KA Animal glycosphingolipids as membrane attachment sites for bacteria. Annu Rev Biochem 1989 58:309 PubMed

4. Kniep B et al. Leukocyte Typing IV (ed. W. Knapp et al.) pp 877-879. OxfordUniversity Press, Oxford (1989)

5. Symington FW CDw17: a neutrophil glycolipid antigen regulated by activation. J Immunol 1989 142:2784 PubMed

6. Symington FW,Bernstein ID,Hakomori S Monoclonal antibody specific for lactosylceramide. J Biol Chem 1984 259:6008 PubMed

7. Thompson JS. In Leukocyte Typing III (ed AJ McMichael edt al), p 713,Oxford University Press, Oxford (1987)

8. Thompson, J.S., and Lund-Johansen, F. Leukocyte Typing V (ed. Schlossmanet al.) pp. 822-823. Oxford University Press, Oxford (1995)

9. Willheim M,Agis H,Sperr WR,Koller M,Bankl HC,Kiener H,Fritsch G,Fureder W,Spittler A,Graninger W,et al Purification of human basophils and mast cells by multistep separation technique and mAb to CDw17 and CD117/c-kit. J Immunol Methods 1995 182:115 PubMed

WWW RESOURCES

* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99 mpr@mail.nih.gov