PROW: CD102

PROW and IWHLDA present the GUIDE on:
CD102
Author: Eiji Takeuchi
Reviewer: Carl G. Gahmberg
[GUIDE BAR]

ALTERNATE NAMES FOR CD102

intercellular adhesion molecule-2, ICAM-2

MAJOR LINKS FOR CD102

NCBI LocusLink Record: 3384
Mendelian Inheritance in Man (OMIM): 146630
SwissProt annotated protein record: P13598

FUNCTION BIOCHEMICAL ACTIVITY OF CD102 - Unknown

CELLULAR FUNCTION OF CD102

Providing costimulatory signal in immune response.
Lymphocyte recirculation

DISEASE RELEVANCE OF CD102 AND FUNCTION OF CD102 IN INTACT ANIMAL - Unknown

STRUCTURE MOLECULAR FAMILY FOR CD102

Families in which CD102 is a member
- CD102-->immunoglobulin supergene family

MOLECULAR STRUCTURE OF CD102

Type I membrane protein (254 amino acids)
Extracellular domain consists of two C2-type immunoglobulin-like domains (202 amino acids)
26-residue transmembrane domain
26-residue cytoplasmic domain

MOLECULAR MASS OF CD102

CELL TYPE	MW UNREDUCED	MW REDUCED	Comment
HUVEC	55-65
B lymphoblastoid cell	55

POST-TRANSCRIPTIONAL MODIFICATION OF CD102 - Unknown

POST-TRANSLATIONAL MODIFICATION OF CD102

Six potential N-Glycosylation sites are in extracellular domain

MOLECULAR INTERACTIONS PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD102 - Unknown

SUBSTRATES FOR CD102 - Unknown

ENZYMES WHICH MODIFY CD102 - Unknown

LIGANDS FOR CD102 AND MOLECULES ASSOCIATED WITH CD102

MOLECULE	COMMENT
LFA-1	Ligand
CD11b/CD18(Mac-1)	This issue is still somewhat controversial (Xie et al. 1995)**

EXPRESSION MAIN CELLULAR EXPRESSION OF CD102

Expressed constitutively on vascular endothelial cells.
Expressed on some population of resting lymphocytes
Expressed on monocytes
Expressed on platelets**
Not expressed on neutrophils.
Induced in lymphomas (Renkonen et al. 1992).**

AUTHOR'S ADDITIONAL INSIGHTS ON CD102 - No information

REAGENTS CD102-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
B-R7 (A071)	Vermot-Desroches C et al., Cedex (Xie et al. 1995)*
B-T1(A076)	Vermot-Desroches C et al., Cedex (Xie et al. 1995)*

SELECTION OF OTHER CD102-SPECIFIC REFERENCE MAB

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
CBR-IC2/1	de Fougerolles AR et al. 1991
CBR-IC2/2	de Fougerolles AR et al. 1991
6D5	Nortamo P et al. 1991

SELECTED REFERENCES ON CD102

REVIEWS

PRIMARY CITATIONS

1. Damle NK,Klussman K,Aruffo A Intercellular adhesion molecule-2, a second counter-receptor for CD11a/CD18 (leukocyte function-associated antigen-1), provides a costimulatory signal for T-cell receptor-initiated activation of human T cells. J Immunol 1992 148:665 PubMed

2. Diamond MS,Staunton DE,de Fougerolles AR,Stacker SA,Garcia-Aguilar J,Hibbs ML,Springer TA ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18). J Cell Biol 1990 111:3129 PubMed

3. Gahmberg CG,Nortamo P,Zimmermann D,Ruoslahti E The human leukocyte-adhesion ligand, intercellular-adhesion molecule 2. Expression and characterization of the protein. Eur J Biochem 1991 195:177 PubMed

4. Li R,Nortamo P,Kantor C,Kovanen P,Timonen T,Gahmberg CG A leukocyte integrin binding peptide from intercellular adhesion molecule-2 stimulates T cell adhesion and natural killer cell activity. J Biol Chem 1993 268:21474 PubMed

5. Li R,Nortamo P,Valmu L,Tolvanen M,Huuskonen J,Kantor C,Gahmberg CG A peptide from ICAM-2 binds to the leukocyte integrin CD11a/CD18 and inhibits endothelial cell adhesion. J Biol Chem 1993 268:17513 PubMed

6. Li R,Xie J,Kantor C,Koistinen V,Altieri DC,Nortamo P,Gahmberg CG A peptide derived from the intercellular adhesion molecule-2 regulates the avidity of the leukocyte integrins CD11b/CD18 and CD11c/CD18. J Cell Biol 1995 129:1143 PubMed

7. Nortamo P,Li R,Renkonen R,Timonen T,Prieto J,Patarroyo M,Gahmberg CG The expression of human intercellular adhesion molecule-2 is refractory to inflammatory cytokines. Eur J Immunol 1991 21:2629 PubMed

8. Nortamo P,Salcedo R,Timonen T,Patarroyo M,Gahmberg CG A monoclonal antibody to the human leukocyte adhesion molecule intercellular adhesion molecule-2. Cellular distribution and molecular characterization of the antigen. J Immunol 1991 146:2530 PubMed

9. Renkonen R,Paavonen T,Nortamo P,Gahmberg CG Expression of endothelial adhesion molecules in vivo. Increased endothelial ICAM-2 expression in lymphoid malignancies. Am J Pathol 1992 140:763 PubMed

10. Staunton DE,Dustin ML,Springer TA Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. Nature 1989 339:61 PubMed

11. Vazeux R,Hoffman PA,Tomita JK,Dickinson ES,Jasman RL,St John T,Gallatin WM Cloning and characterization of a new intercellular adhesion molecule Nature 1992 360:485 PubMed

12. Xie J,Li R,Kotovuori P,Vermot-Desroches C,Wijdenes J,Arnaout MA,Nortamo P,Gahmberg CG Intercellular adhesion molecule-2 (CD102) binds to the leukocyte integrin CD11b/CD18 through the A domain. J Immunol 1995 155:3619 PubMed

13. de Fougerolles AR,Stacker SA,Schwarting R,Springer TA Characterization of ICAM-2 and evidence for a third counter-receptor for LFA-1. J Exp Med 1991 174:253 PubMed

WWW RESOURCES

* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99 mpr@mail.nih.gov