PROW: CD66f

PROW and IWHLDA present the GUIDE on:
CD66f
Authors: Keith Skubitz; Fritz Grunert; Peter Jantscheff; Motomu Kuroki; Amy Skubitz
Reviewer:
Diverse coauthors in lieu of reviewer
[GUIDE BAR]

ALTERNATE NAMES FOR CD66f

Pregnancy specific b1 glycoprotein
SP-1
pregancy-specific glycoprotein, PSG

MAJOR LINKS FOR CD66f

NCBI LocusLink Record: 5669
Mendelian Inheritance in Man (OMIM): 176390
SwissProt annotated protein record: P11462

FUNCTION BIOCHEMICAL ACTIVITY OF CD66f

Unclear, most species contain an RGD motif

CELLULAR FUNCTION OF CD66f

Unclear may be involved in immune regulation and protection of fetus from maternal immune system, necessary for successful pregnancy

DISEASE RELEVANCE OF CD66f AND FUNCTION OF CD66f IN INTACT ANIMAL

Unclear - low levels in maternal blood predict spontaneous abortion

STRUCTURE MOLECULAR FAMILY FOR CD66f

Families in which CD66f is a member
- CD66f-->carcinoembryonic antigen-->immunoglobulin supergene family

MOLECULAR STRUCTURE OF CD66f

Leader 34aa, external 286 or 378aa, short hydrophilic sequences 2-13aa
Soluble protein
2 or 3 Ig C2 domains and 1 IgG-V like domain

MOLECULAR MASS OF CD66f

CELL TYPE	MW UNREDUCED	MW REDUCED	Comment
Found in serum		54-72 kDa

POST-TRANSCRIPTIONAL MODIFICATION OF CD66f

Many splice variants from 11 highly conserved PSG genes

POST-TRANSLATIONAL MODIFICATION OF CD66f

Heavily and variably N-glycosylated; (4-8 N-glycosylation sites)

MOLECULAR INTERACTIONS PROTEINS AND DNA ELEMENTS WHICH REGULATE TRANSCRIPTION OF CD66f - No information

SUBSTRATES FOR CD66f - No information

ENZYMES WHICH MODIFY CD66f - No information

LIGANDS FOR CD66f AND MOLECULES ASSOCIATED WITH CD66f - Unclear

EXPRESSION MAIN CELLULAR EXPRESSION OF CD66f

Produced in placental syncytiotrophoblasts, fetal liver, myeloid cell lines
Produced in placenta and released

AUTHOR'S ADDITIONAL INSIGHTS ON CD66f

The data are consistent with the hypothesis that CD66f may protect the fetus from the maternal immune system

REAGENTS CD66f-SPECIFIC MABS NEWLY ASSIGNED AT SIXTH INTERNATIONAL WORKSHOP - See reference mAb

SELECTION OF OTHER CD66f-SPECIFIC REFERENCE MAB

NAME(Workshop IDs)	SOURCE or REFERENCE	COMMENT
G3	Janice Chou, National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892
IID10	Janice Chou, National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892

SELECTED REFERENCES ON CD66f

REVIEWS

PRIMARY CITATIONS

1. Tatarinov YS Trophoblast-specific beta1-glycoprotein as a marker for pregnancy and malignancies. Gynecol Obstet Invest 1978 9:65 PubMed

2. Thompson JA,Grunert F,Zimmermann W Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. J Clin Lab Anal 1991 5:344 PubMed

3. Watanabe S,Chou JY Human pregnancy-specific beta 1-glycoprotein: a new member of the carcinoembryonic antigen gene family. Biochem Biophys Res Commun 1988 152:762 PubMed

4. Oikawa S,Inuzuka C,Kuroki M,Matsuoka Y,Kosaki G,Nakazato H A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene. Biochem Biophys Res Commun 1989 163:1021 PubMed

5. Barnett TR,Pickle W 2d,Elting JJ Characterization of two new members of the pregnancy-specific beta 1- glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit. Biochemistry 1990 29:10213 PubMed

6. Teglund S,Olsen A,Khan WN,Frangsmyr L,Hammarstrom S The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA) family. Genomics 1994 23:669 PubMed

WWW RESOURCES

* indicates ammended by reviewer, ** indicates added by reviewer

Portions copyright by Garland Press and by the International Workshops on Human Leukocyte Differentiation Antigens; used with permission

Modified 10/14/99 mpr@mail.nih.gov